Originally the International Society for Clinical Biostatistics was governed by The Rules of the Society adopted at the General Meeting on 14 September 1982.
These Rules were revised at General Meetings on 11 September 1984; 18 September 1986; 9 September 1987; 1 September 1988; 20 September 1990, and 18 August 1992.

The Rules were replaced by the Constitution adopted at the General Meeting on 27 August 1996 and revised on 1 April 2002 and 31 December 2008, following postal ballots, and on 31 December 2012 and 27 October 2018 following electronic ballots.

The Society is registered as an association in Geneva, Switzerland [Répertoire des Enterprises du Canton de Genève (REG)]]. To conform with Swiss Law, a “Statutes of Association” document was created and approved by the membership (also 27 October 2018).